Hi, becca! It's not the medications but rather the person taking it as every person is affected differently by every drug. As they say, it's a crap shoot.
In my own case I was on several antidepressants, including Pristiq, before I switched to Effexor and never gained an ounce on any of them.
You can help minimize the weight gain with diet and exercise, but these drugs can potentially change some people's metabolism so for them weight gain is inevitable.
Effexor has been great for me and I'd take it even if I did gain weight.
Good luck to you! WCV
bluebecca2878; Just wanted to add to that I have been on Effexor for 10 years or so and have not gained anything from it weight wise, And this goes for a lot of people that are on it. Plus the way you change some eating habits as we are all different and react differently but i feel the odds are on your side. Have a good weekend. Chuck1957
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