Will be starting Enbrel very soon and very nervous about this. I also take 25 mg. of injectable methotrexate, 200mg of celebrex and currently also on prednisone. Prednisone works so well for me , I wander why not just leave me on that. I know there are side effects but are they any worse than the side effects of biologics? All of these ra drugs are sure scarey, would prefer not to have to take them at all. Prednisone is the least scarey one to me at the moment. Any help with this is very appreciated.