I've been on a wide variety of drugs the past 12 months for my OCD. Started with Effexor, then changed to Luvox, and now I'm on Lexapro. Unfortunately, my symptoms (intrusive thoughts, anxiety, depression) haven't gotten any better even though I'm on a really high dose of Lexapro (40mg). My doctor is planning to switch me from Lexapro to Clomipramine and was wondering if anyone with OCD has had success with Clomipramine? I'm at my wits end with medication changes. Thanks for the responses!