I have been taking Lamictal 400mg/day (200 twice daily) and Seroquel XR 600mg at bedtime for 4 years. My original manic symptoms were not euphoric, they were insomnia, agitation, and psychotic symptoms. So I was put on the higher dose of Seroquel. But it never happened again. I have been chronically mildly depressed ever since, although stable. I often question my diagnosis. I had extreme stress then and think it may have been psychotic depressive episode and severe anxiety. Later I was also put on Effexor XR 300mg/day and Klonopin 3mg/ day. Anxiety improved, but can't seem to get out of this chronic depression/dysphoria. My psychiatrist still sticks with Bipolar I with mixed features as my diagnosis. At least I'm functioning somewhat normally now.
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