... thought it was causing weight gain, at the time I was on Cymbalta for panic attacks but started to have anxiety about 6 months after I cut back on the Saphris. I stopped Cymbalta and have tried Zoloft, Celexa and now Effexor for my anxiety/panic - none of which seem to helping much -in fact I think it has become worse since I stopped Cymbalta. I'm having less panic but more everyday anxiety. I'm now wondering if the Saphris may have been helping my anxiety! Any help would be appreciated! Thanks!