Are there any others taking SAM-e with their antidepressants? I just started Pristiq a few weeks ago & I am waiting for it 2 kick in full force. I also started taking SAM-e to help. My therapist did tell me some time ago that she recommends SAM-e, but I don't see a lot of posts on it! Maybe, because it does cost too much! I am also waiting for a generic version of Pristiq also! Is there anyone else feeling like me? Can you guys tell me any of your esperiences with Pristiq, SAM-e or a combination with similar ADs? Let me know, thanks for any & all replies! I hope ya'll can relate or will let me know soon. Thanks! Bless you all!