How long did it take for you guys to see the medicine take effect?

Week one was good and i had less appetite. Week two, with 2 pills AM and 1 PM, all the effects were gone. No more nausea, sleep trouble, hot flashes and i regained my appetite. Today is my first full dose day (2 @AM, 2 @PM). I am worried the medicine is ineffective.

Thoughts anyone?