I was taking Effexor 75 mg and my doctor added Celexa 20 mg to that. I'm concerned because of serotonin syndrome but she says she uses this combo often. I have depression, anxiety/GAD and OCD. Thanks in advance.
Has anyone ever been prescribed an SSRI (Celexa) and an SNRI (Effexor) at the same time?
- 3 Jul 2014 by mulder228
- 17 January 2018
- celexa, effexor, depression, anxiety, obsessive compulsive disorder, generalized anxiety disorder, doctor, prescription, syndrome, ssri, serotonin-norepinephrine reuptake inhibitors
I have not but I do know that bipolar people (such as myself) are often on as many as 5 meds at a time with at least 2 being seratonin meds. I go to support groups and that's what they tell me. I understand your concern though. Just be aware of any side effects you have and call ur doctor or go to the ER at your first concern.
I would not be especially concerned with seretonin syndrome since the Effexor (venlafaxine) was prescribed at a low dose (37.5 mg and 75 mg are typically starting doses) and Celexa can be taken up to 40-60mg/day. Effexor is an SNRI that targets seretonin and norepinephrine reuptake, while Celexa is a well-reviewed SSRI that blocks seretonin uptake.
I am more curious as to why your physician chose to add an SSRI to your regimen instead of titrating your Effexor up to a more therapeutic level? Depending on formulation (immediate release (IR) or extended release (XR) versions), Effexor has demonstrated efficacy in daily amounts up to 225 mg - 300 mg in XR formulation and up to 375 mg in IR version.
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