my husband has Myosthenia Gravis (diagnosed last September) Neuromuscular Dr. prescribed prednisone (20mg per day)and Mestinon... He was getting weaker and "not himself"... he has had an 4 year battle for his health..prednisone was used at high doses several times..he is "not himself" on it..very moody, waits away, has had several really bad infections while on it, no energy,or desire to do anything, breathing trouble, .. Dr. says it is the disease... I read a new publication on Drugs.com about Prednisone written 11/2012 and took it up with all of his specialists... it says that Prednisone and Mestinon should not be used together... we weaned him off it (SLOWLY)and he has been off it now about 7 weeks. he is MUCH BETTER stronger, much more active, HIMSELF! he only uses Mestinon as needed so he has needed about 3 pills in the last 7 weeks..if he is fatigued we hear his tongue trouble return, one Mestinon and a few minutes and he is better. He is type 1 diabetic, so he is on insulin and mucinex daily and he takes Protandim. He is golfing 6 or 7 times a week
I have been on Mestinon and Prednisone since 1992 for Myasthenia Gravis.
I have also had the plasmapharesis, surgery to remove the thymus gland, and more recently, the IVIg treatment. I am currenntly on 60mg Mestinon 4X daily and 10mg prednisone daily. The prednisone has been as high as 60mg daily at onset, and as low as 5mg every other day, and I have had very good results with these dosages and have been able to live a pretty normal life.
I realize that it varies with the severity of the disease, the patient and the doctor, but as much as I'd like to be off it, I have accepted the fact that it's necessary in my case. I am
76 years old today, and am pretty active for such and old fellow!
The fact he has the physical strength to continue golf, is a very good sign.
Mestinon is a drug that should be taken continuously for best results. Not on and off, nor on as needed basis. Perhaps your neurologists can help adjust his dosing to help with the ups and downs.
In regards to taking both drugs, so many people do both, that I'd love to read the article or have the link to the site to read more.
I personally can't take steroids, so only on Mestinon. Have done all other therapies, surgery, plasma exchange, IVIG, drugs, and at this point my options are only Mestinon.
I wish I could help with your concern, but I can only share what I know.
Again , I'd like to read your material.
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