I have eaten before taking them, but not even Immodium will stop it. Thanks!
Does anyone know if Oxycodone causes severe diarrhea?
- Asked
- 5 Jul 2012 by Valariekim
- Updated
- 20 Sep 2016
- Topics
- diarrhea, oxycodone
Responses (4)
Not usually. Oxycodone may cause a decrease in the secretion of hydrochloric acid in the stomach that reduces motility while increasing the tone of the antrum, stomach, and duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm resulting in constipation. Oxycodone is one drug that is notorius, even among other opioids, for causing constipation. That being said, most drugs have side effects of nausea, vomiting, constipation AND diarrhea. It is possible that it is causing diarrhea but more likely, it is something else. You can try stopping the drug to see if the diarrhea goes away. Have you just rotated to oxycodone from another drug? Perhaps it could be more of a withdrawal symptom from another opioid? Just guessing there. I would just advise you to talk to your Dr about it.

Further Information
- Oxycodone Information for Consumers
- Oxycodone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Oxycodone (detailed)
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Thanks so much!
Dzoo,
Great explanation of the intricacies of opioid induced constipation. Even I understood. Go girl...
Hip
Thanks so much!
My doctor advised me that in constipation your system gets backed up eventually causing a break like a dam breaking resulting in diarrhea.