I've noticed that water has a horrible aftertaste since I've been using cholestyramine. My Dr ordered it for chronic diarrhea. He's still trying to determine the cause. I've had an upper gi with barium swallow and a colonoscopy. Everything has looked normal. He's running blood tests now to check for Chrones and celiac disease. I still have my gal bladder and all of my bowel. I just wondered about the taste change. Water tastes foul and spoiled. I've tried water from various places and used various cups or bottles.