I'm on 150 mg of Effexor xr for 8 weeks now, slowly worked my way up. I have MDD with Anxiety. I have notice benefit on this dose, but not enough so doc increased it to 187.5. This is the second time pdoc has done this increase and each time my depression returns with a vengeance. So I need to know... Is it normal to have increase of depressive symptoms when you increase Effexor? I've always backed down to the 150 after a couple of days because I can't take the depression returning so bad. Anyone else experienced this? It puts me in a weird situation. I need more benefit, but can't seem to take the increase. Thoughts???