I've had depression off and on my entire life, and also was on the Fentanyl patch for over 12 years - I never noticed it changing my level of depression. Last summer I tried to get off the patch, and after lowering the dose over three months I could not tolerate the pain. I decided to go on Methadone 90 mg to treat the chronic pain and nerve pain. I'm not sure what triggered this deep depression, but it does coincide with starting the Methadone. Has anyone else experienced deep depression while on Methadone? (I realize chronic pain patients often have a level of depression, but this is significant because of it's severity). Thank you!