I have been on 4 different anti-depressants this year.. started out with Lexapro, it was a miracle... for a while.. then I was back to being ultra low and unmotivated. Next, was Cymbalta, which was again good but wore off and I was in tears and unmotivated. After that I went to Prozac.. which made my brain foggy..I couldn't concentrate.. I was making stupid errors in work and forgetting common tasks so i had to leave that behind for Pristiq, been on it for a week I keep getting little headaches.. sometimes they flair and then just fade away.. but it happens everyday.. all day it comes and goes.. i'm hoping this GOES AWAY because my other areas are fine. I'm happier, more motivated and even finding some weight loss. Anyone else have these weird come and go headaches?