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Has anyone found any connection between liver cirrhosis and h. pylori?

Responses (1)

coloresue 30 Jun 2015

H. pylori is a spiral-shaped bacterium found in the stomach, which (along with acid secretion) damages stomach and duodenal tissue, causing inflammation and peptic ulcers.
There is significant association between H. pylori infection and PHG (portal hypertensive gastropathy) in cirrhotic
patients which is also related to severity of PHG. Thus, H.(Heliobacter) pylori needs to be eradicated in cirrhotic patients with PHG. Source: annalsgastro dot gr

In another study, the significantly high prevalence of H. pylori on 153 cirrhotic patients was at the rate of 76.5%. The 1010 blood donors from the same area had a 41.8% infection rate of H. pylori. The rate of infection was higher in patients over 40 years of age, in patients with previous hospital admissions and those having had upper GI endoscopies due to peptic ulcers. The H. pylori infections were not associated with the cirrhosis. Source: link dot springer dot com

Per another study: In summary, from the clinical point of view, some evidence suggests that Helicobacter pylori infection might be relevant in the pathogenesis of hepatic encephalopathy (a disease in which the functioning of the brain is affected by some agent or condition such as viral infection or toxins in the blood) in cirrhosis. The data being generated with respect to a direct hepatotoxicity (acting directly on the liver in a toxic way) are, at present, stimulating but only speculative. pubmed dot gov

In plain language, no direct connection or problem has been proven between H. pylori and cirrhosis of the liver.

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