I take 50mg twice daily of seroquel for my bp & bpd I also take 5 mg four times daily of hydrocodone for back pain & S I joint dysfunction & 325/50/40 of fioricet for headaches I also am on hormone replacement therapy. I only take the fioricet as needed for very bad headaches but does anyone know if there is any long term effects of taking these meds together on a regular basis? Also want to know if there are any interactions with these meds? I take all of them on a regular basis except the fioricet.