I have had depression issues for most of my life (as well as a lot of family). I tried Zoloft when I was in my late teen years and it made me feel lethargic and my thinking and memory was basically blank, so I stopped taking it. After about 5 years I met with a psychiatrist who basically said that my depression was more associated with dopamine and I had ADD and since I wasn't hyperactive as a kid that I was never diagnosed. He prescribed me Bupropion xl 150 and eventually up to 300. It worked great, I was able to focus on school work and had more energy than I had ever had. No more scatter brain and daydreaming, even on subjects that I had no interest in I was able to do the school work. But I didn't continue taking the Bupropion after a couple years for various reasons. (fast forward to now im 36) In the last 2 or 3 years I have started feeling depressed in more of a "hopeless" feeling. So I went to my doctor and asked for the Bupropion. I recently started taking Bupropion SR about 3 months ago. It seems that when I take it, I feel good amount of nervous energy but not focused energy. Very "scatter brained" almost like I had a lot of caffeine, especially when taken on an empty stomach. I met with a psychiatrist and told him about how im feeling more hopless and how the Bupropion was affecting me. He explained to me about the difference between SR an XL. I also informed him that I had taken Bupropion in the past with great success. I explain how I have done research and found that a lot of times Bupropion with an SSRI can sometimes be a better combo. So he started me on Lexapro 10mg and has me lowering my dose of the Bupropion (taking every other day instead of daily).
I am not sure about taking the Bupropion every other day? As it is not prescribed like that. Maybe other Community members will comment on that.
I used to be on Bupropion 150 XL brand name worked well. But when I went back on it I was prescribed generic 100 SR. It made my anxiety increase, what you call nervous energy. It also was not pulling me out of my depression. FYI I did find out that SR can be cut in half because the time release is in the tablet not in the coating. But you have to keep the other half in an air tight container until used.
I have been on the SR for 6 weeks and my psych doc added Lexapro 5 mg brand name. I have only been on the Lex 5 days now. It has helped with the anxiety and a little with the depression. But it is too soon to tell. I am a bit skeptical of my meds until they hit the 3-8 month mark. I requested Brand Lex because I had horrible side effects with the generic. From what I have researched and from others that are on both, it appears to be a good combo since they affect different neurotransmitters.
I hope this combo works for both of us :) Let me know how it goes if you can since we are both on the same meds.
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