I have had depression issues for most of my life (as well as a lot of family). I tried Zoloft when I was in my late teen years and it made me feel lethargic and my thinking and memory was basically blank, so I stopped taking it. After about 5 years I met with a psychiatrist who basically said that my depression was more associated with dopamine and I had ADD and since I wasn't hyperactive as a kid that I was never diagnosed. He prescribed me Bupropion xl 150 and eventually up to 300. It worked great, I was able to focus on school work and had more energy than I had ever had. No more scatter brain and daydreaming, even on subjects that I had no interest in I was able to do the school work. But I didn't continue taking the Bupropion after a couple years for various reasons. (fast forward to now im 36) In the last 2 or 3 years I have started feeling depressed in more of a "hopeless" feeling. So I went to my doctor and asked for the Bupropion. I recently started taking Bupropion SR about 3 months ago. It seems that when I take it, I feel good amount of nervous energy but not focused energy. Very "scatter brained" almost like I had a lot of caffeine, especially when taken on an empty stomach. I met with a psychiatrist and told him about how im feeling more hopless and how the Bupropion was affecting me. He explained to me about the difference between SR an XL. I also informed him that I had taken Bupropion in the past with great success. I explain how I have done research and found that a lot of times Bupropion with an SSRI can sometimes be a better combo. So he started me on Lexapro 10mg and has me lowering my dose of the Bupropion (taking every other day instead of daily).