I was prescribed Amitriptyline 50 mg. 2 years ago for extreme anxiety and ruminating in the morning and depression. It worked right away! I was so relieved to not be afraid to wake up in the morning. Unfortunately, after a couple of weeks, I started experiencing LPR (reflux in the throat) mainly exhibited by a tight and constant cold feeling in my throat, right down to my stomach. I stopped taking the Amitriptyline, but it took a year before the LPR went away. I have had GERD multiple times in the past due to stress. Please let me know if you have had this problem of LPR as a side effect from Amitriptyline. Maybe I was taking too high a dose? I'm 5'5" and weigh 140 lbs. Thanks!