I take 24Mg caps twice per day and need to take 5 mg tabs once or twice per day of prednisone to control the itching that results from amitiza. The amitiza was prescribed for gastroparesis from long term diabetes although insulin controlled with A1c of about 6.2. The need to take prednisone has raised the A1c a bit and made control more difficult. In an attempt to make life a little easier, Amitiza has been dropped and another dose of miralax has been added to my usual two miralax per day and three Metamucil. So far, so good.