I've been using Protopic on my face for years. More often than not, it has significantly helped the eczema on my face. More recently though, I have been getting a lot of swelling in my neck and face and eyes. I've used the Protopic on my neck also but pretty much avoided my eyes but have on occasion used it close to my eyes. No one can figure this swelling out. I've reading more about the effects of the protopic and wonder if there is a correlation.