I’ve taken Plaquenil before with no ill effects but quit taking it as I just got too lazy to remember. Well, i’m Back on it and like after a week of taking it, my anxiety has gotten so bad that my appetite has gone way down and I feel nervous all the time and have negative thoughts like my life is meaningless. Could be the time of year or stress over my boyfriend borrowing lots of money from me but just wondered if anyone could attest to the medicine possibly being the culprit.