I've been on Cymbalta for 6 yrs and in the last year or so it has not been working as well. For the first few years it was a wonder drug for me, I had been taking Zoloft prior to that with little to no effect. This summer I had a major depressive episode and spent a week at an inpatient facility. The doctor I saw there added Seroquel XR and initially it helped. But over the last four months I've had a series of less serious depressive episodes with a few periods of normalcy that last a few days and then right back to depression. So, my doctor suggested trying Viibryd. I'm wondering though, is it OK to take with Seroquel? Has anyone had this combination? If so, what have your experiences been? I'm not as worried about side-effects as I am overall response to depression on this combination.