The very first Butrans patch I put on started to mold, at least that is what I believe it to be, after 5 days. That is when I noticed it, it started to itch real bad and I looked at it in the mirror and saw black spots and black edges around the patch. My husband inspected it and he too believed it to be mold. I called my doctor but they had not heard of any such thing or anyone else complaining about this happening to them. If anyone else has had this happen to them please let me know. Thank you!!