My dr prescribed Contrave, and I was able to lose about 20 lbs. in just two or three months. It was great! Then, unfortunately, my psychiatrist changed my antidepressant, and I gained 20 lbs back quickly. I gained even more weight back just from emotional eating, because I was going through a very stressful situation. My dr prescribed Contrave again, when I was ready to start eating right, and it did nothing for me. I took it for a couple of months while eating right and exercising and I just didn't lose. So discouraging! My dr said maybe I built up a resistance. Has this happened to anyone? I'm wondering if that resistance will wear off and the Contrave will work again after a while, but I can't find any information about this issue.