I was just upped to 150 mgs of Effexor - was on 75mgs for 8 years . First anti-depressant I used but after a panic attack and bout of depression I upped it. I have been on the 150mg for 12days but I feel so much worse. Like a lot worse. It's Sunday so I can't call my doctor . Could I take one of my 75 mgs tonight? Would it give me any side effects? I can't handle this ... Can upping your dose of Effexor make it worse and not get better or does it always get better?