Poor absorption due to low solibility problem
I can't think of any new drugs of that sort. The idea now would be to make the drug in a particular salt form which would have relative solubility for maximum effect. Drugs are expensive and manufacturers have to ensure they design them in a particular way that solubility does not have an effect on bioavailability otherwise I'm sure consumers won't be very happy. Certain things like avoiding first pass metabolism cannot be built into the medicine but they can use the most soluble form of the medicine to make a tablet/capsule, etc.
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