Currently I take 60 mg cymbalta and 300 mg wellburtin Xl. I take both at night. Stated off good first two weeks but my anxiety got really bad during the third week. I feel like I am close to a meltdown. However my depresion is under control. I have been taken wellburtin for years but cymbalta for 3 weeks. Befor cymbalta I took Prozac. I have been on antideprants for 11 years. Either ssri or snri. I still can't find the right one.