... Effexor at the same time as I am going up on the Zoloft. I am having my period at this time and I am dealing with overwhelming feelings of guilt over the past. Little things that I might have said or did that I didn't think would be a big deal ends up in my head like a big deal. Sometimes it can be things that happened a long time ago are coming back and bothering me. Any tips or ideas of what i can do?