I am 4 weeks into pristiq... 50 mg/ day... i think i am seeing alittle light at the end of the tunnel. I still seem to have this soul crushing anxiety first thing in the am. If i power through it and force myself to go out then it seems to get better but never completely goes away. But I have a lot of days where i just seem to sit and wonder if i will ever feel normal again... fortunately i am slow with work right now. This whole fatigue thing has been getting worse for the last few years... sucking it up is becoming increasingly harder to do. I guess im hoping that someone is going to tell me is that the meds will somehow magically kick in one day and this will all be over