I have to take large doses of opioid medication due to chronic pain. I've been on them for 10 years. I was diagnosed with MDD 30+ years ago. I found that ADs don't seem to offer complete relief now. After familiarization with how the brain & its reward system works (chemically) this now makes sense yet my Psychiatrist keeps prescribing ADs for the MDD. Has anyone found depression/motivation relief while taking opiods and ADs? If yes, can you please let me know what ADs worked for you. Also the details of your pain medications taken at the same time. I'm sorry I ever started this particular treatment for my pain & really am in desperate need for relief from the depression & lack of interest and motivations for anything in life.