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Anticholinesterase Poisoning - why does inhibition of anticholinesterase cause death?

Responses (1)

Marvell 11 Jan 2010

Inhibition of anticholinesterase would result in excess acetylcholine in the synpases.

Too much acetylcholine would cause excessive muscle contractility.

acetylcholine excites neurons in the brain and many other parts of the body, including muscle tissues and glands. Acetylcholine is released where nerves meet muscles and is therefore responsible for muscle contraction.

After acetylcholine stimulates its receptors, it is quickly inactivated and destroyed by an enzyme. Drugs that keep this enzyme from working are used to treat myasthenia gravis, a disease of muscle weakness and fatigue. These drugs lead to an excess of acetylcholine in synapses and overstimulation of the muscles. The result in patients with extreme muscle weakness is normal muscle contraction.

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