I have bipolar disorder I and PMDD. I take birth control pills without placebos ever. I recently had a bunch of MRSA lesions and was put on minocycline for 3 months. I've been on the antibiotics for a couple wks and I'm having breakthrough bleeding, endometriosis cramps, hot flashes and worst of all, anxiety and depression increase. Mostly depression. I feel nauseous and fatigued all the time. My docs know about this and there doesn't seem to be anything they can do about the side effects of antibiotics. I've tried a bunch of different antibiotics and they all cause the same problems. I take Zofran sometimes. I'm thinking of asking my OBGYN if there's a stronger birth control dosage (I know there is a higher dosed pill of the same brand I take) that I could use until I'm off the minocycline. Anybody been through or know about this sort of problem?