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Anemia - Sickle Cell - Any hope for a cure in the future?

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robo 9 Aug 2009

from https://www.drugs.com/enc/sickle-cell-anemia.html

Sickle cell anemia Treatment

Patients with sickle cell disease need continuous treatment, even when they are not having a painful crisis. Supplementation with folic acid, an essential element in producing red blood cells, is required because of the rapid red blood cell turnover.

The purpose of treatment is to manage and control symptoms, and to try to limit the frequency of crises.

During a sickle crisis, certain treatments may be necessary. Painful episodes are treated with analgesics and enough liquid intake. Treatment of pain is critical. Non-narcotic medications may be effective, but some patients will require narcotics.

Hydroxyurea (Hydrea) is a drug used fro some patients to reduce the number of episodes of pain (including chest pain and difficulty breathing). It does not work for everyone.

Antibiotics and vaccines are given to prevent bacteria infections, which are common in children with sickle cell disease.

Additional treatments for complications may include:

* Dialysis or kidney transplant for kidney disease
* Drug rehabilitation and counseling for the psychological complications
* Gallbladder removal (if there is significant gallstone disease)
* Hip replacement for avascular necrosis of the hip (death of the joint)
* Irrigation or surgery for priapism (persistent, painful erections)
* Partial exchange transfusion for acute chest syndrome
* Surgery for eye problems
* Transfusions or surgery for brain problems, such as strokes
* Wound care, zinc oxide, or surgery for leg ulcers

Bone marrow transplants can cure sickle cell anemia. However, very few people with this disease are able to find a suitable donor. Bone marrow transplantation may also include risks, including infection and rejection.

There are a number of treatments in clinical trials:
GR-ARA-1
https://www.drugs.com/clinical_trials/erytech-pharma-presents-new-advance-sickle-cell-anaemia-6312.html
6R-BH4
https://www.drugs.com/clinical_trials/biomarin-announces-positive-results-phase-2a-clinical-study-6r-bh4-sickle-cell-5806.html
Revimmune Therapy for Bone Marrow Transplant
https://www.drugs.com/clinical_trials/biovest-media-alert-baltimore-sun-reports-first-patientworldwide-cured-sickle-cell-using-3852.html
GMI-1070
https://www.drugs.com/clinical_trials/glycomimetics-inc-highlights-advances-lead-candidate-sickle-cell-patients-international-1616.html

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