I have read that anal fissures off midline may be caused by serious medical conditions such as Crohns and HIV. I have had an itchy anus for years and was prescribed a cream which is effective. I have also had bleeding years previously due to scratching. The cream has now stopped this however i still get cuts and sores around my anus which heals within 1-2 days-they do not lie directly on the midline but not lateral either. Should i be concerned?