I recently weened off Paxil (took for 2 months only 10mg) and started Amitriptyline a few days ago. I started at only 5mg and am now up to 25mg/day. I have no side effects and have been sleeping well, but my depression is back and I'm having panic attacks again. I had horrible side effects with the Paxil (jitteriness and irritability mostly) but it worked in terms of anti-panic and depression. To anyone who has experience taking Amitriptyline after an SSRI: does it take time to work? Just wondering when I should give up because it doesn't seem to be helping my anxiety or depression. Thanks!