I suffer from Crohn's disease and after many surgeries over the years I've been left suffering with severe constipation, along with that is bleeding and agonising pain. After trying all sorts from the healthy bowel clinic I was put on Amitiza at 24mcg daily. After a day or so the nausea started following by vomiting, then the headaches which are unbearable. I stopped taking them for a week and recently started again, unfortunately the side effects are back, and back with a vengeance. How long do,these side effects last? Is it worth persevering with them? Hope someone out there can help. Dorien