Taking 50 mg of Zoloft for anxiety which was showing up in my inability to drive on freeway?I am currently taking 50 mg of zoloft for anxiety which was showing up in my inability to drive on freeway and a hard time driving on the streets so I would go various roots to get home or to work, this was also causing complete anxiety heart palpitations just feeling like someone was going to hit me, or I would hit someone. I was taking 100mg of Zoloft my Dr switched me too Welbutrin xl 150 mg and put the zoloft down to 50 mg because I also want to quit smoking. I have been on both since the 29th of July. I previously took Welbutrin years ago and quit smoking in what seemed like a week, but was unable to stay on it due to the restlessness it was creating I felt like a was crawling out of my skin. I dont seem to have that so much this time. But I am having trouble sleeping and just turning my mind off. Plus it has been 2 weeks I still feel no desire to quit smoking in fact I am smoking more. My Dr told me to give it a couple of more weeks last Friday and if I had not felt like it was working he would up the mg. How long does it usually take for this to work? If I can not quit smoking or keep smoking more I would rather go back on the 100 mg zoloft. ( I was also able to get back on the freeway last month after 4 to 5 months of not being able to. That was with a month and 1/2 on the zoloft.