I have already taken Erythromycin and Clithromycin(cannot remember spelling) for a Strep B infection in my leg. They haven't worked and the ulcer is enlarging. Can you help?
The problem with the ulcer is most likely from circulation and ulcers are always infected with bacteria. Antibiotics can retard healing of ulcers. Do you go to a wound care clinic? To answer your question, a small percentage of people allergic to penicillin are allergic to cephalosporins like keflex. I am allergic to penicillin and I can take cephalosporins.
You need to consult a wound specialist. Like KM mentions, many wounds like this are colonized with bacteria. Depending on the cause of the wound, (is it venous stasis/venous insufficiency, diabetic ulcer, or ischemic-from lack of flow in the artery) it should be treated differently. A venous ulcer often wont heal without compression but for an arterial wound compression would make it worse. From what you describe, I am guessing venous stasis ulcer-they whole wound bed may be yellow or green but that doesnt mean that you need antibiotics necessarily. Staph is all over everyones skin and will colonize an ulcer. The wound needs to be treated by a specialist, especially if this has been going on for more than a few weeks!
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