... MTHFR gene mutation, and I think this will be a good combination to take... starting off on 7.5 this week and then raising it to the full 15mg per day. :) Does anyone know why it's so bad to have alcohol with Deplin? I don't drink often at all but sometimes I like to have some wine or a cocktail, but I'm wondering now that I'm on these 2 meds. I should even risk it. Does anyone know if even one or two drinks on ocassion is really that bad? :-/