Yes, it's possible for antihistamines to lose effectiveness over time, as your histamine receptors will down-regulate (get used to and compensate for) the drug.
I have this problem with all drugs that affect histamine receptors. I can only take drugs like these once or twice a week or they stop being effective. It could just be me, though, with this type of problem.
- Loratadine Information for Consumers
- Loratadine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Loratadine (detailed)
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