I have been on prednisone (20mg daily) for RA for a fortnight and whilst it hasn't completely removed symptoms of pain and swelling it has definitely helped, last night I took my first ever dose of methotrexate (10mg) just to see if I experience any side effects, and while for the most part I haven't had any reactions as of yet I did however wake up in immense pain as if i haven't had anything and were in the midst of a full blown flare up. I have been instructed to still keep taking prednisone until the methotrexate kicks in, has any one else heard of this?