patient took allopurinol 300 mg/day and 2 weeks later was diagnozed with "very severe aplastic anemia". could allopurinol be the cause?
Yes, allopurinol can cause severe aplastic anemia, and I'm sure the effects can become apparent in 2 weeks.
Hematologic side effects including bone marrow suppression, resulting in severe anemia, thrombocytopenia, and leukopenia have been reported in 0.2% of patients. In addition, aplastic anemia, and hemolytic anemia have been reported. At least one case of pure red cell aplasia has also been reported.
- Allopurinol Information for Consumers
- Allopurinol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Allopurinol (detailed)
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