I have Ehlers-Danlos Syndrome Hypermobility Type as well as many associated health issues, I am in chronic pain, and I get unbearable flare ups for which I need to go to the ER to get meds, and thus have to wait hours and go through unnecessary examinations etc. As a result of my EDS I do not metabolize pill form of pain medications. None of the following work: ibuprofen, naproxen, acetaminophen, aspirin, tramaset, Demerol, hydromorphone(only pill form), fentanyl(iv) as well as pain creams. I don't metabolize many non pain-related medications as well. I'm not the type who would abuse drugs, I only use them when I feel like I'm dying.