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Acetaminophen/Caffeine - is excedrin a nephrotoxic?

Responses (2)

JohnySmith 17 Feb 2010

In appropriate use Acetaminophen/Caffeine and excedrin does not possess nephrotoxic action. As with all medications containing acetaminophen, the use of alcohol with Excedrin carries a significant risk of hepatotoxicity. Additionally, aspirin usage is associated with increased risk of gastrointestinal bleeding.

itsmetoo2 17 Feb 2010

"Biotransformation: Approximately 90 to 95% of a dose is metabolized in the liver via the cytochrome P450 enzyme pathways (primarily by conjugation with glucuronic acid, sulfuric acid, and cysteine). An intermediate metabolite is hepatotoxic and most likely nephrotoxic and can accumulate after the primary metabolic pathways have been saturated.
Half Life: 1 to 4 hours"

http://www.flexyx.com/E/Excedrin.html

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