Have been on Pristiq for some time now. Have tried many of the others but they don't seem to do anything for me. However the Pristiq is still not doing it. I still feel depressed, no energy, have stopped doing the things I have enjoyed, don't like being around my family and friends. I need my life back and would like to add Abilify... I also have MS and take Avonex weekly, along with Vicodyne daily for pain. So if you are in the same boat would love to hear your comments.