I don't really know what exactly can happen but this is the advice from manufacturers and FDA.
Do not use Letrozole if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Letrozole is found in breast milk. If you are or will be breast-feeding while you use Letrozole, check with your doctor. Discuss any possible risks to your baby.
Letrozole Pregnancy Warnings
The physician needs to discuss the necessity of adequate contraception with women who have the potential to become pregnant including women who are perimenopausal or who recently became postmenopausal, until their postmenopausal status is fully established.
Letrozole has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity, fetotoxicity, and teratogenicity. There are no controlled data in human pregnancy. Letrozole is not recommended for use during pregnancy. The drug is indicated for postmenopausal women. If a pregnant woman is exposed to letrozole during pregnancy, she should be apprised of the potential hazard to the fetus and potential risk for loss of the pregnancy.
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