When is it best time to take this medicin: with meal or after meal?
It's another interesting question. Platelets are so sensitive to aspirin that a single 81-mg dose will inhibit the stickiness of all the platelets in your body — and the inhibition is irreversible. But if the inhibition is permanent, platelets are not. In fact, they are short-lived cells that are constantly being removed from your blood and replaced by a steady stream of new platelets that pour out from your bone marrow. You need to take aspirin on a regular basis to inhibit these new platelets. Doctors now recommend daily dosing, but the decades-old Physicians' Health Study showed that taking aspirin every other day also works.
Heart attacks and strokes peak in the early morning hours, even before most men would have a chance to take their preventive aspirin. In theory, then, taking aspirin at bedtime would provide maximum platelet inhibition and protection during this vulnerable period. And a 2005 Spanish study found that morning doses of aspirin raise blood pressure, while bedtime doses lower it.
Bedtime aspirin would seem ideal — if you can remember to take it. Most people find it easier to remember to take their medications first thing in the morning than later in the day. If you're one of these, you're much better off taking aspirin faithfully in the morning than erratically at night.
Take it with food if it upsets your stomach.
Source: Harvard University
- Aspirin Information for Consumers
- Aspirin Information for Healthcare Professionals (includes dosage details)
- Side Effects of Aspirin (detailed)
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