... past 5 years. During this time she has also had a 5 verterra spinal fusion. She has always been a very active person but has become increasingly frustrated with feelings of loss of strength and balance in her legs. She says it feels like her skin in her lower legs is too tight or she is walking on cotton. She has had her peripheral nervous system test and all appears fine. Has anyone experienced similar feelings in the lower extremities while on hydroyurea?