Tramadol (Includes Tramadol) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Tramadol and its metabolites, one of which (referred to as M1) is pharmacologically active and a more potent analgesic than tramadol itself, are primarily excreted in the urine. The rate and extent of excretion of both tramadol and M1 have been shown to decrease in patients with impaired renal function. Therapy with tramadol should be administered cautiously in such patients. The manufacturer recommends increasing the dosing interval to every 12 hours, with a maximum daily dosage of 200 mg, in patients with creatinine clearance below 30 mL/min.
I suggest you discuss this interaction with your Dr.
- Tramadol Information for Consumers
- Tramadol Information for Healthcare Professionals (includes dosage details)
- Side Effects of Tramadol (detailed)
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