I am just starting, hoping for some depression relief without having to get to the "meds" necessity. I have had success with Sam-E before, and had this suggested to me because of the lower side effects listed over conventional meds. I guess I want to know how long to expect to be on it before there is some appreciable change in mood, and how long most people stay on it before tapering off. Also, I would like to hear from anyone who has used it successfully, stopped using it, and has not had to start another supplement or med because their moods are stable now without anxiety and depression. Thanks for your assistance.